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. 2015 Jun 18;10(6):e0128618. doi: 10.1371/journal.pone.0128618

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© 2015 Liu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — The four shRNAs shown are potent antivirals that target highly conserved HIV-1 RNA sequences. The Dicer processing sites are indicated (¯I_), with the 3’-guide strand highlighted in grey (◄). Based on these guide strands, four matching Aggo2 molecules were designed against the same HIV-1 targets. The Ago2 processing site is indicated and the 5’-guide is highlighted in grey.