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. 2015 Jun 19;6:118. doi: 10.3389/fphar.2015.00118

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Copyright © 2015 O’Leary and Chahine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Internal MTSET induces a persistent current in the I1770C mutant. (A) The currents of the I1770C mutant measured in reagent-free pipette solution. Currents are shown immediately after break-in (P₁) and after 0.5, 1, 3, 5, and 8 min (P₁₀₀). (B) Currents of the I1770C mutant with 1 mM MTSET in the patch pipette. (C) Peak currents measured in the absence and presence of MTSET. (D) Persistent current measured after 25 ms of depolarization.