Table 3.
Incremental odds of poor cognitive performance at year 4 and of accelerated 4 year cognitive decline according to preceding vascular risk factors
| Risk factor | Poor cognitive function at year 4a | p value | Accelerated cognitive declineb | p value |
|---|---|---|---|---|
| Entire sample (max N = 831) | ||||
| Historical systolic BP | 1.00 (0.98, 1.01) | 0.635 | 1.01 (0.99, 1.03) | 0.228 |
| History of moderate/heavy vs never smoked/history of light smoking | 2.01 (1.38, 2.92) | <0.001 | 1.64 (1.14, 2.34) | 0.007 |
| Pack-years | 1.01 (1.00, 1.02) | 0.001 | 1.01 (1.00, 1.01) | 0.013 |
| Historical HbA1c | 1.24 (1.02, 1.49) | 0.029 | 1.21 (1.00, 1.45) | 0.046 |
| Men (max N = 430) | ||||
| Historical systolic BP | 1.00 (0.97, 1.02) | 0.651 | 1.02 (1.00, 1.05) | 0.053 |
| History of moderate/heavy vs never smoked/history of light smoking | 2.09 (1.25, 3.52) | 0.005 | 1.61 (0.97, 2.66) | 0.065 |
| Pack-years | 1.01 (1.00, 1.02) | 0.036 | 1.01 (1.00, 1.02) | 0.154 |
| Historical HbA1c | 1.34 (1.02, 1.77) | 0.035 | 0.95 (0.73, 1.24) | 0.706 |
| Women (max N = 401) | ||||
| Historical systolic BP | 1.00 (0.98, 1.02) | 0.932 | 1.00 (0.98, 1.02) | 0.802 |
| History of moderate/heavy vs never smoked/history of light smoking | 1.83 (1.06, 3.17) | 0.030 | 1.66 (0.99, 2.77) | 0.054 |
| Pack-years | 1.02 (1.01, 1.04) | 0.003 | 1.02 (1.00, 1.03) | 0.023 |
| Historical HbA1c | 1.14 (0.88, 1.45) | 0.326 | 1.50 (1.15, 1.96) | 0.003 |
Data are ORs (95% CIs) comparing incremental odds of scoring in the lowest tertile of the respective distributions vs the highest tertile
Analyses are multiple logistic regression analyses that were performed separately for each risk factor. Never smoked/history of light smoking was defined as <10 pack-years. History of moderate/heavy smoking was defined as ≥10 pack-years. Pack-years was untransformed in these analyses. Outcome variable is g at year 4. Analyses for entire sample was adjusted for age, sex and in sex-stratified analyses for age. Cut-points for follow-up g: lowest tertile < −0.43; medium tertile −0.43 to 0.48; highest tertile >0.48. Cut-points for follow-up g adjusted for baseline g: lowest tertile < −0.39; medium tertile −0.39 to 0.44; highest tertile >0.44
aModel of reduced cognitive function at year 4 was defined as scoring in the lowest tertile of g at year 4
bModel of accelerated 4 year cognitive decline was defined as scoring in the lowest tertile of year 4 g adjusted for baseline g