Fig. 1.

Polymorphisms in the GR and GLCCI1 genes. The GR gene consists of nine exons and is located on chromosome 5. The BclI (mutant G allele) and N363S (mutant G allele) SNPs have been associated with increased GC sensitivity in vivo, whereas the 9β (mutant G allele) and the ER22/23EK (GAGAGG → GAAAAG) polymorphisms have been linked to decreased GC sensitivity in vivo. Rs37972 is located 865 base pairs upstream of exon 1 of the GLCCI1 gene. The GC-S group consists of all patients with GR haplotype 1 and/or haplotype 2 and did not carry haplotype 3 or 4. Patients in the GC-S group who also carried the wild-type GLCCI1 genotype were classified as GC-SS. Patients with GR haplotype 3 or 4, and did not carry haplotype 1 or 2, were grouped as GC-I. Patients in the GC-I group who also carried one or two mutant GLCCI1-T alleles were attributed to the GC-II group