TABLE 2.
Loci with allelic differences between sublineages 23.1 (n = 300) and 23.2 (n = 60) among genes hypothesized to play a role in meningococcal virulencea
| BIGSdb Neisseria locus identifier | Predicted protein/function (gene) | Allele no. (% of isolates with this allele): |
% nucleotide identity | No. of amino acid differences | |
|---|---|---|---|---|---|
| 23.1 | 23.2 | ||||
| NEIS0537 | Two-component system regulator; ompR family | 2 (100) | 1 (100) | 99.6 | 0 |
| NEIS1853 | Multidrug resistance translocase (farA) | 148 (97) | 10 (98) | 95.1 | 35 |
| NEIS1852 | Multidrug resistance translocase (farB) | 117 (92) | 130 (98) | 98.1 | 4 |
| NEIS0577 | Iron-uptake permease inner membrane protein (fbpB) | 1 (98) | 5 (98) | 99.8 | 0 |
| NEIS1963 | Enterobactin receptor (fetA) | 223 (95) | 30 (82) | 49.1 | 42 |
| NEIS0624 | 3-Deoxy-manno-octulosonate cytidylyltransferase (kdsB) | 33 (99) | 14 (100) | 99.9 | 1 |
| NEIS0899 | Alpha-2,3-sialyltransferase/LOSb alpha chain transferases (lst) | 241 (90) | 25 (95) | 99.91 | 1 |
| NEIS0528 | Periplasmic binding protein | 3 (99) | 38 (93) | 98 | 4 |
| NEIS0661 | Hypothetical protein | 29 (100) | 2 (100) | 99.8 | 0 |
| NEIS0612 | Outer membrane protein (nspA) | 92 (99) | 17 (100) | 99.8 | 1 |
| NEIS1632 | Outer membrane lipoprotein (mtrE) | 62 (96) | 5 (98) | 97.9 | 4 |
| NEIS0487 | Type IV pilin/pilus-associated protein | 102 (89) | 48 (80) | 88.7 | 22 |
a
From the collection of 177 putative Neisseria virulence genes described in reference 22.
b
LOS, lipooligosaccharide.