TABLE 3.
Loci with allelic differences of genes hypothesized to play a role in meningococcal virulencea between the two subtypes of the predominant strain type YI
| BIGSdb Neisseria locus identifier | Predicted protein/function (gene) | Allele no. (% of isolates with this allele) |
% Nucleotide identity | No. of amino acid differences | |
|---|---|---|---|---|---|
| Subtype 1 | Subtype 2 | ||||
| NEIS0048 | UDP-glucose epimerase/LPSb synthesis (galE) | 38 (100) | 169 (100) | 99.1 | 0 |
| NEIS0669 | Ferrochelatase (hemH) | 45 (100) | 9 (100) | 95.4 | 13 |
| NEIS1902 | Lacto-N-neotetraose biosynthesis glycosyl transferase/LOSc alpha chain transferases (lgtA) | 79 (98) | 22 (100) | 99.0 | 2 |
| NEIS1901 | Lacto-N-neotetraose biosynthesis glycosyl transferase/LOS alpha chain transferases (lgtB) | 81 (98) | 24 (100) | 96.4 | 13 |
| NEIS0421 | Lipid A biosynthesis lauroyl transferase (lpxL2) | 70 (100) | 11 (100) | 99.9 | 1 |
| NEIS1513 | AraC family transcriptional regulator (mtrA) | 43 (98) | 6 (100) | 99.9 | 0 |
| NEIS1634 | Membrane fusion protein (mtrC) | 88 (96) | 41 (100) | 99.9 | 1 |
| NEIS1965 | Putative inner membrane transport protein | 279d (100) | 61 (100) | 99.9 | Frameshift |
| NEIS2198 | Outer membrane adhesin (opcA) | 18 (94) | 86d (100) | 99.9 | Frameshift |
| NEIS0396 | Pilin glycosylation protein (pglD) | 51 (100) | 200 (83) | 100.0 | 1 |
a
From the collection of 177 putative Neisseria virulence genes described in reference 22.
b
LPS, lipopolysaccharide.
c
LOS, lipooligosaccharide.
d
Allele sequence contained an internal stop codon.