TABLE 4.

Variants with potential NS3 and NS5A resistance-associated amino acid positions

Patient IDa	GTb	RAV(s) for each position in proteinc:
		NS3											NS5A
		V36any	F43any	T54any	V55any	Q80any	S122R	R155any	A156any	D168any	I170A/T/L	L175L	K24G/N/R	M28A/G/T	Q30any	L31any	P32L	S38F	H58D	A92K/L	Y93any
A	1a											L
B	1b														R	L/M
C	2a	L				G						L			K	M
D	2b	L				G	R					L			K
E	2b	L				G	R					L			K	M
F	2c	L				G	R					L			K	F
G	2c	L				G	R					L			K	M
H	2j	L				G	R					L			K	M
I	3a	L								Q		L			A
J	3i	L								Q		L			K
K	4a	L										L			S	M
L	4d	L										L			R	M
M	5a	L				K						L									T
N	6a					K									R						T
O	6a					K									R						T
P	6e														S						S
Q	6j														A						T

^aID, identification.

^bGT, genotype.

^cSubstitutions show positions in NS3 and NS5A gene with corresponding wild-type amino acid first (from 1a H77 reference genome) and the amino acid(s) associated with second. For each patient, the presence of amino acids associated with resistance is shown in the table. Blank cells indicate identical amino acid as that of 1a wild type, which has not been associated with resistance.