TABLE 5.

Variants with potential NS5B resistance-associated amino acid positions

Patient IDa	GTb	RAVc
		NI					NNI																			RBV
		L159any	S282any	C289any	L320any	V321any	S96any	N142T	C316any	M414I/T/V	L419any	R422K	M423any	C445F	Y448any	Y452any	I482any	A486any	V494A	P495any	P496S	A499A	G554S	S556G	D559G	T390I	F415Y
A	1a																					A
B	1b																										Y
C	2a			M							I			F			L		A			A		G			Y
D	2b			M							I			F			L		A			A		G			Y
E	2b			M							I			F			L		A			A		G			Y
F	2c			M							I			F			L		A			A	S	G			Y
G	2c			M							I			F			L		A			A	S	G			Y
H	2j			M							V			F			L		A			A		G			Y
I	3a			F							I			F			L					A		G			Y
J	3i			F							I			F			L					A		G			Y
K	4a			F						V	I			F			L					A		G			Y
L	4d			F						I	I			F			L					A		G			Y
M	5a			M									I	F								A		G			Y
N	6a			M							I			F			L	G	A			A
O	6a			M							I			F			L	G	A			A
P	6e			L							I			F			L		A			A					Y
Q	6j			M							I			F			L		A			A					Y

^aID, identification.

^bGT, genotype.

^cSubstitutions show positions in NS5B gene and their wild-type amino acid first (from 1a H77 reference genome) and the amino acid(s) associated with resistance second. For each patient, the presence of amino acids associated with resistance is shown in the table. Blank cells indicate identical amino acid as that of 1a wild type, which has not been associated with resistance. NI, nucleoside inhibitor; NNI, non-nucleoside inhibitor; RBV, ribavirin.