Top row (periodic acid–Schiff (PAS) staining) (A-C): Glomerular damage in the affected areas. Middle row PAS staining) (D-F): Tubular damage in the affected areas. Lower row (hematoxylin-eosin (HE) staining) (G-I): Tubulointerstitial inflammatory infiltration. Saline-injected control rats (A,D,G); CD-DXR: doxorubicin-injected (5 mg/kg) CD rats (B,E,H); BH-DXR: doxorubicin-injected BH rats (C,F,I). J: Sirius red staining (100x). L: Fibronectin immunohistochemistry (400x). K, M: computerized quantification of the immunostained areas. CD: CD rats, BH: BH rats. c: saline-injected, DXR: Doxorubicin-injected rats (5 mg/kg). *: p<0.05 vs. strain-identical, control group, †: p<0.05 vs. CD/DXR, control group.