Table 3. Comparison of doxorubicin-injected (DXR) Rowett, black hooded (BH) and Charles Dawley (CD) rats with similar proteinuria (BH/DXRp and CD/DXRp subgroups).
| CD/DXRp (n = 4) | BH/DXRp (n = 5) | P value | |
|---|---|---|---|
| U Protein, week 8 (mg/24h) | 396.5±82.2 | 362.5±30.3 | 0.42 |
| Nephrin | 0.68±0.16 | 0.87±0.19 | 0.19 |
| U NGAL, week 8 (mg/24h) | 10.1±2.0 | 5.2±1.6 | <0.01 |
| Sirius red (%) | 18.0±1.6 | 11.8±1.0 | <0.01 |
| Fibronectin (%) | 7.91±2.45 | 5.55±1.19 | 0.16 |
| TGF-β1 | 6.00±2.36 | 2.13±1.23 | <0.05 |
| CTGF | 3.71±2.10 | 0.54±0.11 | <0.05 |
| COL1A1 | 23.09±6.14 | 5.79±2.41 | <0.01 |
| p47 phox | 4.69±1.51 | 1.95±0.36 | <0.05 |
| p91 phox | 10.69±2.47 | 1.94±0.78 | <0.01 |
| MCP-1 | 9.23 3.28 | 3.46±0.99 | <0.05 |