Table 6.
Main risk factors associated with overall mortality (Cox regression analyses)
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| p | OR | CI (95 %) | p | OR | CI (95 %) | |
| Recipient age >60 years | 0.740 | 1.07 | 0.697–1.663 | |||
| Anti-HCV+ | 0.839 | 0.96 | 0.654–1.412 | |||
| HCC | 0.063 | 1.53 | 0.978–2.395 | 0.049 | 1.60 | 1.002–2.584 |
| Pretransplant renal dysfunction | 0.030 | 1.90 | 1.064–3.412 | 0.043 | 1.83 | 1.020–3.292 |
| Donor age >40 years | 0.245 | 0.78 | 0.529–1.177 | |||
| Steatosis >20 % | 0.059 | 0.64 | 0.407–1.017 | |||
| Portal thrombosis | 0.268 | 1.32 | 0.804–2.192 | |||
| CIT >8 h | 0.301 | 0.81 | 0.552–1.201 | |||
| WIT >60 min | 0.028 | 1.60 | 1.052–2.444 | 0.016 | 1.68 | 1.103–2.586 |
| Severe reperfusion injury | 0.490 | 0.79 | 0.413–1.527 | |||
| CyA induction | 0.720 | 1.09 | 0.665–1.805 | |||
| Risk factors associated with long-term survival (after excluding deaths over 1st year post-transplant) | ||||||
| CMV infection | 0.277 | 1.36 | 0.780–2.376 | |||
| Acute rejection | 0.171 | 1.45 | 0.852–2.468 | |||
| Chronic rejection | 0.005 | 2.26 | 1.289–3.991 | |||
| Vascular complications | 0.004 | 3.20 | 1.445–7.103 | |||
| Biliary complications | 0.277 | 1.34 | 0.786–2.314 | |||
| Retransplant | 0.442 | 1.29 | 0.673–2.480 | |||
| Arterial hypertension at 1 year | 0.028 | 2.01 | 1.078–3.765 | |||
| Diabetes mellitus at 1 year | 0.001 | 6.94 | 3.131–15.398 | 0.001 | 6.03 | 2.339–15.574 |
| Dyslipidemia at 1 year | 0.001 | 3.68 | 1.953–6.934 | |||
| Renal dysfunction at 1 year | 0.106 | 1.53 | 0.913–2.573 | |||
| Liver dysfunction at 1 year | 0.002 | 2.20 | 1.334–3.643 | 0.050 | 2.29 | 1.000–5.261 |
HCV hepatitis C virus, HCC hepatocellular carcinoma, CIT cold ischemia time, WIT warm ischemia time, CyA cyclosporine, OR odds ratio, CI confidence interval