Table 2B.
Results for SPM whole brain analyses for gray and white matter volumes; and for small volume corrected ROIs, which passed the initial threshold, but were not significant after FWE-cluster correction.
| MNI-coordinate peak |
p-Value FWE-cluster corrected |
|||||||
|---|---|---|---|---|---|---|---|---|
| Comparison | Region | k | x | y | z | F-peak | Z-peak | |
| Whole brain | ||||||||
| HT ∗ MDD | MCC | 2247 | 9 | −31 | 45 | 25.1 | 4.75 | .011 |
| HT ∗ MDD | Cerebellum | 2138 | −28 | −69 | −50 | 13.6 | 3.37 | .014 |
| Small volume corrected | ||||||||
| MDD− > MDD+ | IFG | 56 | −52 | 27 | 30 | 12.07 | 3.24 | .740 |
| MDD− > MDD+ | 31 | 54 | 17 | 0 | 9.44 | 2.83 | .811 | |
| MDD− > MDD+ | ACC | 241 | −2 | 38 | 10 | 11.07 | 3.09 | .370 |
| HT ∗ MDD | 467 | −3 | 36 | 10 | 13.58 | 3.45 | .163 | |
| HT ∗ MDD | Hippocampus | 13 | −14 | −4 | −21 | 9.29 | 2.80 | .868 |
FWE-cluster corrected p < .05 at initial threshold p < .005; k > 50. GM = gray matter; HT = hypertension; MDD = major depressive disorder; MCC = mid-cingulate cortex; IFG = inferior frontal gyrus; ACC = anterior cingulate cortex; k = cluster size; MNI-coordinate = coordinates of the voxel showing peak significance in mean MNI-space (defined by the Montreal Neurological Institute). Comparisons in the analyses: main effects of HT and MDD and interaction effects of HT ∗ MDD, adjusted for scan location, sex, age and anxiety. HT ∗ MDD = interaction effect; MDD− > MDD+ = lower GM for participants with MDD.