Table 1.

LAT expression and function

Protein	Gene	Substrates	Expression pattern
LAT1	SLC7A5	Leu, Ile, Phe, Met, Tyr, His, Trp, Val	Brain, spleen, placenta, ovary, testis, colon, blood-brain barrier, fetal liver, activated lymphocytes [5,6]
LAT2	SLC7A8	Gly, Ala, Ser, Thr, Asn, Gln, Met, Leu, Ile, Val, Phe, Tyr, Trp, His	Jejunum, ileum, kidney, placenta, brain, liver, skeletal muscle, prostate, ovaries, fetal liver, testis and heart [7-9]
LAT3	SLC43A1	Met, Leu, Ile, Val, Phe	Pancreas, skin, muscle, liver, kidney podocytes, prostate [10,20,23,25]
LAT4	SLC43A2	Met, Leu, Ile, Val, Phe	Placenta, kidney, peripheral blood leukocytes [11]