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Enhanced formation of radiation induced chromosomal aberrations by SAHA and GDC-0449 in H1299 cell line. A. Representative chromosome aberrations induced by combining SAHA, GDC-0449, and SAHA + GDC-0449 with 1 Gy IR. B. The combination of SAHA + GDC-0449 significantly increased formation of chromosomal aberrations in comparison to all other treatment groups. Arrows, chromosomal aberrations. *P < 0.05.
