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. 2015 Apr 1;113(10):3798–3815. doi: 10.1152/jn.00923.2014

Fig. 7.

Fig. 7.

Anesthetics increased spike-field coherence (SFC) in V1 during visual stimulation, preferentially at low frequencies. A: SFC was used to quantify the interaction between mesoscopic LFP frequency structure and microscopic MUA during presentation of the visual stimulus. This figure shows group-averaged SFC by cortical depth during presentation of visual stimulation. Left: SFC was low in awake animals across cortical layers. Right: anesthesia induced layer-specific changes to SFC (0.5%, 0.75%, and 1.0% iso all with xylazine). Specifically, compared with awake animals, anesthetized animals exhibited increased SFC in supragranular and infragranular layers, increased SFC at low frequencies in granular layers, and decreased SFC at higher frequencies in granular layers. Putative granular layer IV (electrode depth 0.3–0.6 mm) is indicated by red box. B: the SFC ratio (mean SFC from 0.5 Hz to 30 Hz/mean SFC from 30 Hz to 40 Hz) was used to indicate the relative enhancement of low-frequency SFC. In supragranular layers, anesthetics enhanced SFC broadly across frequencies compared with SFC in the awake animal. C: in granular layers, anesthetics enhanced SFC in low frequencies in a dose-dependent manner and decreased SFC at higher frequencies compared with SFC in awake animals. D: anesthetics enhanced SFC in low frequencies most prominently in infragranular layers. Error bars indicate 1 SE. *Significantly different at P < 0.05.