FIG 1.

Structure of KSHV major latency locus transcripts. Arrows depict mRNA structures. Transcripts of 5.4 to 5.8 kb (tricistronic) encode LANA; 1.7-kb (bicistronic) mRNAs encode v-cyclin and possibly v-FLIP (via an IRES-mediated mechanism). The 1.1-kb (monocistronic) mRNA, previously only detected by RT-PCR, can encode only v-FLIP. Abbreviations: LTc, constitutive latency promoter; LTi, inducible latency promoter; LANA, latency-associated nuclear antigen; v-CYC, virally encoded cyclin homolog; v-FLIP, viral homolog of FLICE-inhibitory protein.