FIG 7.

Viral replication kinetics and plaque phenotypes of rZH501 mutants. (A) Viral replication kinetics (multiplicity of infection, 0.01) in Vero cells or Hepa1-6 cells for rMP-12, rZH501, or the mutants with the Y259H (Gn) and R1182G (Gc) mutations or the Y259H (Gn), R1182G (Gc), and R1029K (L) mutations. (B) Plaque images (top) and plaque sizes (bottom) of rMP-12, rZH501, and the mutants. The graph represents the average + standard error of plaque diameters for 23 randomly selected plaques. **, statistically significant difference by Student's unpaired t test (P < 0.0001) versus the results for rZH501.