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. 2015 Jun 19;5:11405. doi: 10.1038/srep11405

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Copyright © 2015, Macmillan Publishers Limited

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(a) The time-dependent cleavage activity of MD0-7. MD0 is G0, and MD7 is G2501. MD1-7 contain progressive mutations in the following sequential order: C17-, C18-, A13G, T50C, G40A, T6C and T39A. The time points (0–256 h) are set up to reveal both strong and weak activities expected of these DNA molecules. Cropped gels are used for better presentation and these gels were run under the same experimental conditions. The original uncropped gel images are provided in panel C of Figure S2 in the supplementary information. (b) Percent cleavage vs. reaction time.