Figure 4. Reduced production of SCF and TN-C in LPA₄-deficient stromal cells.

(A) The amount of CXCL12 per femur from naïve LPA₄-deficient and WT mice (n = 9). (B,C) The amounts of SCF (B) and CXCL12 (C) per femur from LPA₄-deficient and WT mice (n = 13–14) at day 9 after 5-FU administration. (D-F) Quantitative RT-PCR for Scf (D) Cxcl12 (E), and TN-C (F) mRNA expression in isolated BM stromal cells from LPA₄-deficient and WT mice that were treated with or without LPA (n = 9–10). *P < 0.05 vs. WT.