Figure 1.

Programmable synthetic constructs can be used to assemble nanostructures within living cells in a controlled fashion for leishmanicidal effects; (A) Raw sequence data of proteins, DNA, and RNA can be retrieved from databases; (B) Raw sequence data analysis for selection of a good sequence for nanostructure design followed by designing, modeling, simulation, and visualization of bionanosystems; (C) Computational analysis of the nanostructures for stability, robustness, and evolvability; (D) Generating sequence for tailor made nano-synthetic constructs; (E) Selection of a suitable chassis microorganism for uploading the synthetic construct; (F) Optimum chassis uploaded with the construct for the synthesis of combinatorial nanostructures; (G) Application of the nanostructures in the form of vaccines, aptamers, immune modulators to leishmanial parasite for a leishmanicidal effect.