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. 2015 Jun 19;6:323. doi: 10.3389/fimmu.2015.00323

Table 1.

(A) Nanomedicines; (B) Propelling systems applied to nanodevices; (C) Biomolecules as nanostructures in therapeutics.

(A) NANOMEDICINES AVAILABLE IN THE MARKET AND THEIR INDICATIONS

Drug Nano carrier Application Brand name

Paclitaxel Albumin-bound nanoparticles Metastatic breast cancer Abraxane®
Doxorubicin Liposomes Metastatic breast cancer Myocet®
Doxorubicin PEGylated liposomes Metastatic breast and ovarian cancer; Kaposi sarcoma Caelyx®
Daunorubicin Liposome Kaposi sarcoma DaunoXome®
Amphotericin B Liposome Fungal infections and cutaneous leishmaniasis AmBisome®
Monoclonal sheep antibody PAMAM dendrimers Cardiac marker diagnostic Stratus®

(B) PROPELLING SYSTEMS

Propulsion mode Nano carrier Application

Catalytic Multilayer microtubes (5) Immuno-micromachine-based approach for in vitro detection circulating tumor cells without sample preprocessing (6)
Magnetic Tumbling nanowires (7) Magnetic resonance guided microcarrier for liver chemoembilization (8)
Ultrasound Mutilayer microtubes (9) Acoustically active microbubbles for effective therapies in primary central nervous system lymphoma (10)

(C) BIOMOLECULES AS NANOSTRUCTURES IN THERAPEUTICS

Biomolecule Application

Proteins Self assembly nanopeptide vaccines to display B-cell epitope from the malaria parasite Plasmodium berghei circumsporozoite protein (20)
RNA Transferrin-tagged, cyclodextrin-based polymeric nanoparticles-CALAA-01, contains siRNA that targets the M2 subunit of ribonucleotide reductase for cancer treatment (21)
HIVgp120: tat-rev siRNA chimera, a 16-nt dsRNA used as the scaffold to link the gp120 aptamer; decreases infection by blocking gp120 and prevents replication by silencing tat-rev (22)
DNA Cancer-fighting DNA nanorobots that target specific cells for repair (23)