Table 1.
(A) Nanomedicines; (B) Propelling systems applied to nanodevices; (C) Biomolecules as nanostructures in therapeutics.
(A) NANOMEDICINES AVAILABLE IN THE MARKET AND THEIR INDICATIONS | |||
Drug | Nano carrier | Application | Brand name |
Paclitaxel | Albumin-bound nanoparticles | Metastatic breast cancer | Abraxane® |
Doxorubicin | Liposomes | Metastatic breast cancer | Myocet® |
Doxorubicin | PEGylated liposomes | Metastatic breast and ovarian cancer; Kaposi sarcoma | Caelyx® |
Daunorubicin | Liposome | Kaposi sarcoma | DaunoXome® |
Amphotericin B | Liposome | Fungal infections and cutaneous leishmaniasis | AmBisome® |
Monoclonal sheep antibody | PAMAM dendrimers | Cardiac marker diagnostic | Stratus® |
(B) PROPELLING SYSTEMS | |||
Propulsion mode | Nano carrier | Application | |
Catalytic | Multilayer microtubes (5) | Immuno-micromachine-based approach for in vitro detection circulating tumor cells without sample preprocessing (6) | |
Magnetic | Tumbling nanowires (7) | Magnetic resonance guided microcarrier for liver chemoembilization (8) | |
Ultrasound | Mutilayer microtubes (9) | Acoustically active microbubbles for effective therapies in primary central nervous system lymphoma (10) | |
(C) BIOMOLECULES AS NANOSTRUCTURES IN THERAPEUTICS | |||
Biomolecule | Application | ||
Proteins | Self assembly nanopeptide vaccines to display B-cell epitope from the malaria parasite Plasmodium berghei circumsporozoite protein (20) | ||
RNA | Transferrin-tagged, cyclodextrin-based polymeric nanoparticles-CALAA-01, contains siRNA that targets the M2 subunit of ribonucleotide reductase for cancer treatment (21) | ||
HIVgp120: tat-rev siRNA chimera, a 16-nt dsRNA used as the scaffold to link the gp120 aptamer; decreases infection by blocking gp120 and prevents replication by silencing tat-rev (22) | |||
DNA | Cancer-fighting DNA nanorobots that target specific cells for repair (23) |