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The PK profiles of KAL821 in Gottingen mini-pigs after topical administration of KAL821-MPP. The mean KAL821 concentrations ± SE (nM, n = 3) were shown for choroid (A) and retina (B): Dosed eyes (closed circles), nondosed eyes (open squares). The AUC values were generated using GraphPad Prism v6.0 and ratios of dosed over nondosed eyes were determined. Statistical analysis was performed using the Holm-Sidak method multiple t-test, P values were shown on graphs.
