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. 2015 Jun 18;11(6):e1005254. doi: 10.1371/journal.pgen.1005254

Fig 1. Proposed model for genetic evolution in P. pacificus dauer formation.

Fig 1

A) Conserved features of the dauer formation pathway. In endocrine cells, cholesterol is a substrate for the biosynthesis of dafachronic acid (DA), a DAF-12 ligand that suppresses the ability of DAF-12 to promote dauer formation. B) Model for the RS5134/Ohio strain with one copy of dauerless (dau-1.1). dau-1.1 is expressed in the CAN neuron cells and acts (genetically) to inhibit DAF-12 function and thereby inhibit dauer formation. C) The RS2333/California strain has two copies of dauerless (dau-1.1 and dau-1.2), and a corresponding double effect of inhibition of dauer formation.