Table 2.
Gray matter regions showing a significant correlation with neuropsychological test performance across subjects in both patient groups. A positive bootstrap ratio (BSR) denotes a positive correlation between gray matter volume and cognitive test performance. BSRs are the ratio of a voxels weight divided by the bootstrap-derived standard error, and are equivalent to a z-score. Coordinates and BSRs are listed for the peak voxel of each cluster.
| Region | Cluster size (voxels) | X | Y | Z | BSR | ||
|---|---|---|---|---|---|---|---|
| Frontal | |||||||
| L | Inferior frontal gyrus | 113 | −48 | 45 | 1.5 | 6.50 | |
| R | Inferior frontal gyrus | 23 | 34.5 | 36 | −18 | 4.97 | |
| R | Middle frontal gyrus | 127 | 48 | 48 | 12 | 6.35 | |
| R | Superior frontal gyrus | 92 | 21 | 45 | 34.5 | 5.66 | |
| L | Superior frontal gyrus | 27 | −22.5 | 40.5 | 39 | 4.91 | |
| R | Medial frontal cortex | 133 | 12 | −1.5 | 61.5 | 6.00 | |
| L | Medial frontal cortex | 136 | −7.5 | −19.5 | 52.5 | 5.58 | |
| L | Anterior cingulate cortex | 1127 | −4.5 | 28.5 | 27 | 7.64 | |
| R | Anterior cingulate cortex | 21 | 10.5 | 27 | 28.5 | 4.80 | |
| R | Orbitofrontal cortex | 182 | 1.5 | 22.5 | −10.5 | 5.95 | |
| R | Frontopolar cortex | 87 | 34.5 | 60 | −1.5 | 5.42 | |
| L | Middle cingulate cortex | 283 | −4.5 | −30 | 42 | 5.51 | |
| Parietal | |||||||
| L | Inferior parietal lobe | 334 | −51 | −30 | 46.5 | 6.97 | |
| L | Inferior parietal lobe | 53 | −55.5 | −70.5 | 13.5 | 4.92 | |
| R | Inferior parietal lobe | 45 | 51 | −57 | 49.5 | 5.73 | |
| L | Supramarginal gyrus | 257 | −60 | −48 | 27 | 9.90 | |
| L | Superior parietal lobule | 212 | −21 | −55.5 | 52.5 | 6.23 | |
| R | Superior parietal lobule | 137 | 33 | −39 | 39 | 6.87 | |
| R | Angular gyrus | 234 | 55.5 | −57 | 28.5 | 6.55 | |
| R | Precuneus | 93 | 1.5 | −51 | 39 | 5.11 | |
| L | Posterior cingulate cortex | 735 | −13.5 | −46.5 | 19.5 | −6.71 | |
| R | Posterior cingulate cortex | 609 | 13.5 | −43.5 | 21 | −6.69 | |
| R | Paracentral lobule | 646 | 10.5 | −42 | 73.5 | 6.48 | |
| L | Precentral gyrus | 841 | −18 | −13.5 | 73.5 | 7.54 | |
| R | Precentral gyrus | 24 | 28.5 | −28.5 | 70.5 | 4.99 | |
| R | Postcentral gyrus | 203 | 55.5 | −15 | 43.5 | 6.93 | |
| R | Postcentral gyrus | 297 | 45 | −31.5 | 52.5 | 6.73 | |
| R | Postcentral gyrus | 75 | 21 | −21 | 55.5 | 5.60 | |
| L | Postcentral gyrus | 222 | −49.5 | −18 | 49.5 | 5.81 | |
| Temporal | |||||||
| L | Superior temporal gyrus | 413 | −54 | −21 | 9 | 6.80 | |
| R | Inferior temporal gyrus | 74 | 45 | −37.5 | −16.5 | 6.54 | |
| L | Hippocampus | 30 | −27 | −12 | −15 | 4.95 | |
| L | Amygdala | 27 | −12 | −10.5 | −16.5 | 4.81 | |
| R | Fusiform gyrus | 294 | 40.5 | −13.5 | −36 | 5.94 | |
| Occipital | |||||||
| L | Lingual gyrus | 32 | −30 | −58.5 | −1.5 | −5.72 | |
| L | Lingual gyrus | 42 | −24 | −78 | 0 | −6.79 | |
| Other | |||||||
| R | Insula | 3881 | 37.5 | 0 | −19.5 | 10.41 | |
| L | Putamen | 7444 | −18 | 7.5 | −6 | 7.91 | |
| L | Cerebellum | 209 | −15 | −82.5 | −21 | 5.20 | |
| R | Caudate | 51 | 13.5 | 10.5 | 15 | 5.14 |
BSR = bootstrap ratio.