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Quality of life measures
(A) Mean SF-36 PCS and ASQoL over time; (B) percentage of patients reaching the minimum important difference (MID) for SF-36 PCS and ASQoL over time. The MID was defined as a change of at least –1.8 for ASQoL and at least 3.0 for SF-36 PCS. ASQoL: AS quality of life; SF-36 PCS: Short Form-36 physical component score.
