Table 2.

Between group differences in gray matter volume.

Contrast	Region	p value	KE/radius	z value	x	y	z
1. Whole brain analysis
		p uncorr.
ARMS < HC	Middle frontal gyrus	0.035	790	3.59	−33	57	16
ARMS-AD < HC	Superior frontal gyrus	0.028	874	3.98	−33	57	18
ARMS-nonAD < ARMS-AD	Left superior parietal lobe	0.023	944	4.33	−32	−40	45
2. Region of interest
		p FWE-corr*
ARMS-AD < ARMS-nonAD	Left hippocampus	0.029	5 mm	2.86	−18	−19	−17
ARMS-AD < ARMS-nonAD	Right precuneus	0.042	10 mm	3.23	10	−78	51

The data presented here are from ANOVA of 3 included groups (ARMS-AD, ARMS-nonAD, HC) at a threshold of p < 0.005 uncorrected across the whole brain.

There were no significant differences in the following contrasts: ARMS > HC, ARMS-AD > HC, ARMS-nonAD vs. HC, and ARMS-nonAD > ARMS-AD.

Abbreviations: ARMS, at risk mental state; ARMS-AD, ARMS subjects currently receiving antidepressants; ARMS-nonAD, ARMS individuals without current antidepressant medication; HC, healthy controls; KE, voxels per cluster; x y z, coordinates according to the Montreal Neurological Institute.

Abbreviations: ARMS — at-risk mental state; ARMS-AD — ARMS with antidepressants; ARMS-nonAD — ARMS without antidepressants; KE — voxels per cluster.

^*p < 0.0125 required.