Table 2.
Acronym1 | DNA Sequence2 | Net Charge | Mobility, m.u.3 | Mobility Ratio4 |
---|---|---|---|---|
ss20/1 | GCCTATGAAAGGTCTCGACC | −17 | 3.115 | 0.966 |
ss20/4 | TTTGTGTCCCCCTCTCAGGT | −11 | 2.59 | 0.804 |
ss20/6 | CACAAACCTGTTCTTGGCAG | −7 | 1.58 | 0.490 |
ss20/6 | TCGGACTCTGAGTTTCGGTT | −7 | 1.64 | 0.509 |
ss20/0 | GCCTATGAAAGGTCTCGACC | −19 | 3.22 | 1.000 |
ss23/1 | TTGGCCTATGAAAGGTCTCTCTAAT | −20 | 3.07 | 0.948 |
ss23/0 | TTGGCCTATGAAAGGTCTCTCTAAT | −22 | 3.24 | 1.000 |
ds20/1 | GCCTATGAAAGGTCTCGACCCGGATACTTTCCAGAGCTGG | −36 | 3.24 | 0.953 |
ds20/0 | GCCTATGAAAGGTCTCGACCCGGATACTTTCCAGAGCTGG | −38 | 3.40 | 1.000 |
ds23/1 | TTGGCCTATGAAAGGTCTCTCTAATAACCGGATACTTTCCAGAGAGATTA | −42 | 3.28 | 0.962 |
ds23/0 | TTGGCCTATGAAAGGTCTCTCTAATAACCGGATACTTTCCAGAGAGATTA | −44 | 3.41 | 1.000 |
The acronyms indicate whether the oligomer is single- or double-stranded, the number of nucleotides or base pairs, followed by a slash and the number of positively charged internucleoside DEED linkers. Controls without DEED linkers have a zero following the slash.
The nucleotides in bold precede a cationic DEED linker.
Measured in 20 mM HEPES buffer or 20 mM KDM buffer; the mobilities in these two buffers were equal within experimental error. The average standard deviation of the mobilities was ±0.03 m.u.
Mobility ratio = mobility (charge variant) / mobility (parent DNA with the same number of nucleotides or base pairs).
Average mobility of a closely spaced doublet in the electropherogram.