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The efficacy of MTX-cIBR at different concentrations (0.05–5.0 mg/kg) in suppressing the increase in ankle diameters of arthritis rats compared to arthritis rats treated with vehicle, 0.05 mg/kg MTX, and normal rats. The results were from measuring two paws per rat with n = 7 for arthritis rats and n = 4 for normal rats. * = p-value < 0.05 when compared to vehicle-treated arthritis rats.
