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The effect of increasing doses of MTX-cIBR (0.05–5.0 mg/kg) on the increase in animal bodyweight compared to controls (i.e., vehicle and 0.05 mg/kg MTX). The animals treated with 5.0 mg/kg MTX-cIBR maintained their bodyweight significantly compared to vehicle-treated animals. n = 7 for arthritis rats and n = 4 for normal rats. * = p-value < 0.05 when compared to vehicle-treated arthritis rats.
