. Author manuscript; available in PMC: 2015 Jun 19.

Published in final edited form as: J Pharm Sci. 2012 Apr 26;101(9):3275–3291. doi: 10.1002/jps.23164

Table 1.

The effect of MTX-cIBR on suppressing arthritis in the limbs of rats using different parameters at Day 14.

Treatment	Paw Weight ± SE (g)	AUC Paw Ankle Diameter ± SE	Inflammation Score ± SE	Bone Resorption Score ± SE
Normal + Vehicle	1.7761 ± 0.0262 (100%) ^*	1.927 ± 0.005 (100%) ^*	0.00 ± 0.0 (100%) ^*	0.0 ± 0.0 (100%) ^*
Arthritis + Vehicle	3.5825 ± 0.0866 (0%)	2.420 ± 0.028 (0%)	5.0 ± 0.0 (0%)	3.9 ± 0.4 (0%)
Arthritis + 0.05 mg/kg MTX-cIBR	3.3780 ± 0.1104 (11%)	2.305 ± 0.036 (23%) ^**	4.6 ± 0.2 (9%) ^**	4.0 ± 0.4 (−1%)
Arthritis + 0.2 mg/kg MTX-cIBR	3.4321 ± 0.1212 (8%)	2.336 ± 0.035 (17%)	4.7 ± 0.2 (6%)	4.5 ± 0.2 (−15%)
Arthritis + 1 mg/kg MTX-cIBR	3.4582 ± 0.0850 (7%)	2.309 ± 0.030 (22%)^**	4.9 ± 0.1 (1%)	3.6 ± 0.4 (8%)
Arthritis + 5 mg/kg MTX-cIBR	2.2680± 0.2227 (73%) ^*	2.050 ± 0.049 (75%) ^**	2.2 ± 0.5 (56%) ^*	1.1 ± 0.5 (71%) ^*
Arthritis + 0.05 mg/kg MTX	3.5790 ± 0.0877 (0%)	2.388 ± 0.028 (6%)	4.9 ± 0.1 (3%)	3.1 ± 0.4 (22%)

p-value < 0.01 when compared to Arthritis + Vehicle.

^**

p-value < 0.05 when compared to Arthritis + Vehicle.