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. Author manuscript; available in PMC: 2015 Jun 19.
Published in final edited form as: Psychopharmacology (Berl). 2014 May 15;231(24):4637–4647. doi: 10.1007/s00213-014-3612-4

Figure 4.

Figure 4

An anxiogenic effect produced by acute sulfasalazine administration is reversed by co-administration of the cysteine prodrug N-acetyl cysteine (a) This figure illustrates the amount of time spent in the open arm of an elevated plus maze by rats pretreated with vehicle (N=9) or sulfasalazine (8–16 mg/kg, IP; N= 5–11/group) two hour (h) prior to testing. * p<.05 indicates a significant reduction relative to vehicle-treated subjects (two-sided Dunnett’s T). (b) This panel presents the amount of time spent in the open arm of an elevated plus maze by rats pretreated with vehicle (N=4), sulfasalazine (8 mg/kg, IP; N= 5–9/group; administered 2 h prior to testing), and/or N-acetyl cysteine (100 mg/kg, IP; administered one h prior to testing). * p<.05 indicates a significant difference relative to vehicle-treated subjects (two-sided Dunnett’s T).

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