Expert segmentation lesion count, LTPR and LPPV per lesion size groups. The plot on the left shows the manually outline lesion count per each lesion volume group (<0.05, 0.05–0.10, >0.10 ml), averaged across all subjects. The LTPR and LPPV measurement experiments were conducted with a patch radius of 1 voxel, a search area radius of 5 voxels and a pre-selection of 50 training subjects on the 108 RRMS subjects.