TABLE 3.
Interaction of the zinc binding motif with other amino acids within the M2-1 monomer
| Amino acida | Hydrogen bond (bond length inÅ) |
Ionic interaction | ||
|---|---|---|---|---|
| Main chain-main chain | Main chain-side chain | Side chain-side chain | ||
| C7 | A5 (3.34) | Y9 (3.46) | C15 (3.80) | |
| Y9 (3.23) | E10 (3.56) | C21 (3.90) | ||
| E10 (2.99) | F23 (3.79) | C25 (3.63) | ||
| V11 (2.99) | N24 (3.58) | |||
| N24 (2.87) | ||||
| C15 | E10 (3.07) | C7 (3.80) | ||
| R17 (3.80) | C21 (3.86) | |||
| C25 (3.47) | ||||
| C21 | F23 (3.63) | C7 (3.90) | ||
| C15 (3.86) | ||||
| C25 (3.59) | ||||
| H25 | Y27 (3.43) | E10 (3.80) | C7 (3.63) | E10 (3.9) |
| F23 (3.10) | C15 (3.47) | |||
| C21 (3.59) | ||||
a
Data were collected using the hMPV M2-1 structure (PDB ID 4CS7). The bond length is indicated in parentheses in each column. C15 is also involved in the interprotein interaction between chains in the tetramer. There are four chains (A, B, C, and E) in the tetramer. C15 (chain E) interacts with S75 (chain A), and C15 (chain B) interacts with T76 (chain E).