FIG 1.

VP1 amino acid variations in JCPyV genotypes and crystal structure of WT3 VP1. (A) Classification of JCPyV strains into seven genotypes by phylogenetic analysis reveals VP1 amino acid variations (33). Colored spheres highlight residues differing between Mad-1 and WT3 VP1. Strain specific variations can be found within single genotypes. Bold letters indicate amino acids in Mad-1 VP1. N- and C-terminal residues (gray) are not included in the JCPyV Mad-1 VP1 crystal structure (24). (B) Crystal structure of WT3 VP1 pentamer with one VP1 monomer depicted in green. Spheres highlight residues (colored as in panel A) that differ between WT3 and Mad-1 VP1.