FIG 2.

Survival of weanling mice inoculated with rJEV mutants and control viruses. Groups of 10 mice were inoculated with virus or mock infected and monitored for 21 days for signs of encephalitis. All viruses were inoculated at a dose of 10⁴ PFU i.p. Most viruses were screened at a dose of 10² PFU i.c., except for rJEVmut14-14-2 and JEV SA14-14-2, which were tested at a dose of 10⁴ PFU i.c. Experiments 1 and 2 were performed independently, and a statistical comparison with wild-type rJEV is shown in Table 4.