TABLE 5.

Neurovirulence (i.c. LD₅₀) of rJEV mutants in weanling mice

Virus	Dose (PFU)	No. of alive mice/total no. of mice	Median survival time (days)	LD50 (PFU)
rJEVmut14-14-2	104	6/6	>21	>10,000
rJEVmutE	104	6/6	>21	>10,000
	103	6/6	>21
	102	6/6	>21
rJEVmut11	104	2/6	8.5	3,162
	103	4/6	>21
	102	6/6	>21
	101	6/6	>21
rJEVmut3	104	1/6	7	1,995
	103	5/6	>21
	102	4/6	>21
	101	6/6	>21
rJEVmut1	102	0/6	6	0.3
	101	1/6	8.5
	100	3/6	15.5
	10−1	5/6	>21
rJEVmut7	102	0/6	5.5	0.3
	101	0/6	6
	100	1/6	6.5
	10−1	5/6	>21
rJEV	102	0/6	6	0.7
	101	0/6	6.5
	100	3/6	17
	10−1	5/6	>21
Mock	NAa	6/6	>21	NA

^aNA, not applicable.