TABLE 1.

EC₅₀ of pharmacological inhibitors in HPV31 DNA replication assays supported by different E1 proteins

Inhibitor	EC50
	WT E1	E1Δ protein	PUBS-E1Δ protein
Aphidicolin	760 ± 86 nM	1,368 ± 380 nM	1,105 ± 23 nM
Ara-C	380 ± 81 nM	558 ± 165 nM	651 ± 18 nM
Hydroxyurea	312 ± 33 μM	466 ± 106 μM	302 ± 17 μM
Mimosine	193 ± 5 μM	144 ± 19 μM	177 ± 5 μM