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EC50 of catalytically inactive USPs in HPV31 DNA replication assays supported by different E1 proteinsa
| USP1ci | WT E1 |
E1Δ protein |
PUBS-E1Δ protein |
|||
|---|---|---|---|---|---|---|
| EC50 (ng) | Imax (%) | EC50 (ng) | Imax (%) | EC50 (ng) | Imax (%) | |
| 1 | 11 | 87 | 32 | 19 | 11 | 73 |
| 12 | 34 | 72 | NA | NA | 27 | 40 |
| 46 | 38 | 70 | NA | NA | 75 | 50 |
| 1 + 12 + 46 | 20 | 75 | NA | NA | 15 | 58 |
EC50, amount of USPci plasmid needed to inhibit HPV DNA replication by 50%; Imax, maximal level of inhibition achievable with high amounts of USPci; NA, not applicable.
