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(A) Bilateral caudate regions demonstrating significantly greater connectivity with right M1 within HC, compared to PwMS. (B) Greater connectivity within the right hemisphere's cortico-striatal loop was associated with poorer adaptation, particularly within PwMS. Imaging data are overlaid on an averaged 1 mm Talairach anatomical template for display. M1 = primary motor cortex; PwMS = persons with multiple sclerosis; HC = healthy controls.
