Table 2.
Patient demographics for study cohort comparing the total cohort to those that achieved optimal DPE (NED) and those that achieved optimal RT (Appropriate). p-values refer to the comparison of the distribution of patient characteristic between those that achieved NED or appropriate RT and those that did not. N-0, no nodal disease; N-1 nodal disease; T-1 not tumor invasion of adjacent structures; T-2 tumor invasion of adjacent structures.
| Baseline Characteristic | Total (n=161) | NED (n=43) | Appropriate RT (n=38) | p-value comparing NED (n=43) to other patients (n=118) | p-value comparing appropriate RT (n=38) to other patients (n=123) |
|---|---|---|---|---|---|
| Count (%) | Count (%) | Count (%) | |||
| Age (years) | |||||
| <1 | 5 (3%) | 2 (5%) | 1 (3%) | ||
| 1 to 9 | 118 (73%) | 29 (67%) | 29 (76%) | ||
| 10+ | 38 (24%) | 12 (28%) | 8 (21%) | 0.49 | 0.93 |
| Histology | |||||
| Embryonal | 84 (52%) | 20 (49%) | 22 (61%) | ||
| Alveolar | 65 (40%) | 21 (51%) | 14 (39%) | 0.27 | 0.57 |
| Tumor Size | |||||
| ≤ 5 cm | 39 (24%) | 12 (28%) | 10 (26%) | ||
| >5 cm | 121 (76%) | 31 (72%) | 28 (74%) | 0.54 | 0.83 |
| Tumor Stage | |||||
| 2 | 33 (20%) | 8 (19%) | 9 (24%) | ||
| 3 | 128 (80%) | 35 (81%) | 29 (76%) | 0.83 | 0.65 |
| Tumor Invasion | |||||
| T-1 | 88 (55%) | 25 (58%) | 26 (68%) | ||
| T-2 | 72 (45%) | 18 (42%) | 12 (32%) | 0.72 | 0.06 |
| Anatomic Sites | |||||
| Extremity | 63(39%) | 23 (53%) | 17 (45%) | ||
| Bladder Dome | 24 (15%) | 6 (14%) | 6 (13%) | ||
| Trunk/Retroperitoneum/Perineal/Perianal/Intra-thoracic/GI/Biliary | 74 (46%) | 14 (33%) | 16 (42%) | 0.07 | 0.75 |
| Response at week 12 | |||||
| NR | 30/149 (20%) | 6 (14%) | 5 (16%) | ||
| PR | 101/149 (68%) | 23 (53%) | 17 (45%) | ||
| CR | 18/149 (12%) | 14 (33%) | 16 (42%) | <0.001 | <0.001 |