. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Arthritis Rheumatol. 2014 Aug;66(8):2222–2233. doi: 10.1002/art.38639

Table 1.

Inflammation profile^*

	5 weeks		10 weeks		20 weeks
	WT mice (n = 5)	PLG^−/− mice (n = 4)	WT mice (n = 5)	PLG^−/− mice (n = 4)	WT mice (n = 5)	PLG^−/− mice (n = 7)	PLG^−/− FBG^−/− mice (n = 4)	PLG^−/−FBGg^390–396A mice (n = 5)
IL-12p70	87.15 ± 46.35	59.51 ± 21.71	71.45 ± 24.46	65.98 ± 31.84	69.76 ± 23.73	54.12 ± 15.00	73.83 ± 23.37	55.29 ± 32.48
TNFα	26.51 ± 7.37	26.9 ± 12.56	22.13 ± 7.22	30.91 ± 2.31	25.28 ± 6.97	29.08 ± 13.78	27.05 ± 7.64	24.92 ± 9.28
IFNγ	11.82 ± 8.45	7.81 ± 2.35	7.40 ± 2.41	8.05 ± 3.30	8.72 ± 2.85	8.66 ± 5.99	9.43 ± 2.96	5.75 ± 0.71
MCP-1	55.41 ± 0.70	56.76 ± 2.86	55.95 ± 1.33	56.35 ± 1.57	70.88 ± 12.32	63.66 ± 9.99	76.05 ± 6.46	58.47 ±2.52
IL-10	55.99 ± 2.13	55.56 ± 2.31	62.35 ± 14.08	56.61 ± 7.25	58.28 ± 2.19	67.16 ± 30.23	60.85 ± 12.85	55.13 ± 3.59
IL-6	21.39 ± 6.9	27.07 ± 18.05	19.21 ± 6.23	41.07 ± 22.81	24.91 ± 5.5	46.56 ± 24.42^†	24.03 ± 7.306	34.74 ± 19.16

Values are the mean ±SD pg/ml. PLG^−/− = plasminogen-deficient; FBG^−/− = fibrinogen-deficient; FBGg^390–396A = deficient in the α_Mβ₂ binding site of fibrinogen; IL-12p70 =interleukin-12 p70; TNFα =tumor necrosis factor α; IFNγ = interferon-γ; MCP-1 = monocyte chemotactic protein 1.

^†

P<0.05 versus wild-type (WT) mice.