. 2015 Jun 15;8:1471–1482. doi: 10.2147/OTT.S84687

Table 1.

Characteristics of studies included in the meta-analysis

First author	Year	Country	Ethnicity	Specimens	Cancer type	Number	Method	Cut-off	Analysis	Survival^*
Gupta⁵	2010	USA	Caucasian	Tissue	Breast cancer	132	qRT-PCR	125-fold compared with normal tissue	Multivariate	OS,^a MFS^a
Lu¹⁹	2012	Italy	Caucasian	Tissue	Breast cancer	336	qRT-PCR	10.01 expression index	Multivariate	OS,^a RFS^a
Li²⁴	2014	People’s Republic of China	Asian	Tissue	Breast cancer	30	qRT-PCR	.270-fold increased levels	Univariate	OS^b
Sorensen¹⁷	2013	Denmark	Caucasian	Tissue	Breast cancer	164	Microarray	Density plot of gene expression of 0.6	Multivariate	MFS^a
Kim¹⁴	2015	Korea	Asian	Tissue	Cervical cancer	111	qRT-PCR	30-fold compared with normal tissues	Univariate/multivariate	OS,^b RFS^a
He¹²	2014	People’s Republic of China	Asian	Tissue	Endometrial cancer	145	ISH	An staining index score of 6	Univariate	OS^a
Huang¹³	2014	People’s Republic of China	Asian	Tissue	Cervical cancer	218	qRT-PCR	Median expression value of HOTAIR	Multivariate/univariate	OS,^a DFS^b
Qiu¹⁶	2014	People’s Republic of China	Asian	Tissue	Ovarian cancer	64	qRT-PCR	Median value of HOTAIR expression levels	Univariate	OS,^b DFS^b

Notes:

^*,a

Denoted as obtaining HRs directly from publications;

denoted as extracting HRs from Kaplan–Meier curves.

Abbreviations: DFS, disease-free survival; HOTAIR, HOX transcript antisense intergenic RNA; HRs, hazard ratios; ISH, in situ hybridization; MFS, metastasis-free survival; OS, overall survival; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; RFS, recurrence-free survival.