Table 2.
Independent and dependent variables in Box–Behnken experimental design
| Independent variables | Levels | ||
|---|---|---|---|
| Molecular weight of chitosan (X1)* | 1 | 2 | 3 |
| Percentage of chitosan (X2) | 1 | 2 | 3 |
| Percentage of Eugenol (X3) | 0.25 | 0.50 | 0.75 |
| Dependent variables |
Constraints
|
||
| Low | High | Goal | |
| Spreadability % (Y1) | 2.9 | 4.1 | Maximize |
| Acyclovir permeated % (Y2) | 40 | 83 | Maximize |
Note:
*
Chitosan of low molecular weight was coded (1), chitosan of medium molecular weight was coded (2), and chitosan of high molecular weight was coded (3).