Table 5.
Skin permeation parameters for ACV across abdominal rat skin from different formulations in comparison with marketed ACV cream
| Permeation parameters | Marketed ACV cream | ACV-NE hydrogel | Raw ACV hydrogel |
|---|---|---|---|
| Q (μg/cm2) | 1,406 | 2,209 | 1,047 |
| Jss (μg/cm2⋅min) | 8.377 | 13.125 | 6.184 |
| P (cm/min) | 8.3×10−4 | 1.31×10−3 | 6.1×10−4 |
| D (cm2/min) | 12.84×10−5 | 30.38×10−5 | 7.08×10−5 |
| EF | 1.342 | 2.11 | NA |
Abbreviations: ACV, acyclovir; NE, nanoemulsion; Q, cumulative amount permeated; Jss, steady-state flux; P, permeability coefficient; D, diffusion coefficient; EF, enhancement factor; NA, not applicable.