Table 2.
Location, extent, and significance of each local maxima with altered functional connectivity to pelvic floor motor cortex (PFMC) in men with CP/CPPS compared to healthy controls (HC). MNI coordinates in mm.
| Region (hemisphere) |
Peak coordinates |
Cluster size |
Z-score |
GUPI-pain regression |
|---|---|---|---|---|
| Connectivity seed: pelvic-motor (referenced to hand-motor) |
||||
| Less in CP/CPPS vs. HC | ||||
| Posterior insular cortex (right) | 50, −6, 2 | 736 | 4.35 | p = 0.046, R = −0.38 |
| Posterior insular cortex, Brodmann area 13 (right) | 48, 2, −6 | Same cluster | 3.72 | p = 0.074, R = −0.34 |
| Superior temporal gyrus, Brodmann area 22 (right) | 66, −2, 6 | Same cluster | 3.66 | p = 0.224, R = −0.24 |
| Superior temporal gyrus, Brodmann area 22 (right) | 52,2,−2 | Same cluster | 3.59 | p = 0.037, R = −0.40 |
| Posterior insular cortex (right) | 42, −4, 4 | Same cluster | 3.36 | p = 0.016, R = −0.45 |
| Inferior frontal gyrus, Brodmann area 44 (right) | 56, 14, 8 | Same cluster | 2.98 | p = 0.204, R = −0.25 |