Table 6.

Top ten ranked genetic pathways shared between TMAO and CRC.

TMAO ∩ CRC (OMIM)	TMAO ∩ CRC (GWAS)	TMAO ∩ CRC (OMIM) ∩ CRC (GWAS)
Pathways in cancer Immune system Neurotrophin signaling pathway Cell cycle Wnt signaling CMYB pathway Adaptive immune system MYC activpathway MARK signaling pathway Hemostasis	Immune system Cell cycle Pathways in cancer Metabolism of proteins TCA cycle and respiratory electron transport MYC activpathway Adaptive immune system WNT signaling MAPK signaling pathway Metabolism of lipids and lipoproteins	Immune system Cell cycle Pathways in cancer WNT signaling Adaptive immune system MYC activpathway MAPK signaling pathway Chromosome maintenance Telomere maintenance Metabolism of lipids and lipoproteins