Table 4.
Factors associated with adherence in exposed HCWs/HCSs on HIV post-exposure prophylaxis
| Characteristic | Adherence Status1 | Crude hazard ratio [95 % CI] | p-value | Adjusted hazard ratio [95 % CI] | p-value | |
|---|---|---|---|---|---|---|
| Adhered | Defaulted | |||||
| Drug regimen | ||||||
| 3TC/AZT −28 days | 42 | 33 | 1.00 | 1.00 | ||
| 3TC/AZT-3 days | 101 | 0 | 1.79 [1.25–2.56] | 0.002 | 1.75 [1.16–2.66] | 0.008 |
| 3TC/AZT/LPV-RTV −28 days | 32 | 20 | 1.10 [0.69–1.74] | 0.688 | 1.02 [0.56–1.88] | 0.938 |
| Gender | ||||||
| Female | 102 | 29 | 1.00 | |||
| Male | 73 | 24 | 0.97 [0.72–1.31] | 0.824 | - | - |
| Age range (years) | ||||||
| 18–30 | 129 | 32 | 1.00 | |||
| 31–40 | 34 | 16 | 0.85 [0.58–1.24] | 0.395 | ||
| 41–50 | 6 | 4 | 0.75 [0.33–1.70] | 0.489 | ||
| >51 | 6 | 1 | 1.07 [0.47–2.43] | 0.872 | - | - |
| Risk assessment | ||||||
| Low | 103 | 11 | 1.00 | 1.00 | ||
| Medium | 36 | 20 | 0.71 [0.49–1.04] | 0.079 | 0.91 [0.60–1.39] | 0.672 |
| High | 36 | 22 | 0.69 [0.47–1.00] | 0.052 | 1.05 [0.56–2.00] | 0.871 |
| Type of exposure | ||||||
| Percutaneous | 165 | 46 | 1.00 | |||
| Mucocutaneous | 10 | 7 | 0.75 [0.40–1.42] | 0.382 | - | - |
| Profession | ||||||
| Nurses | 65 | 17 | 1.00 | |||
| HCS | 19 | 5 | 1.00 [0.60–1.67] | 0.996 | ||
| Laboratory Staff | 9 | 7 | 0.71 [0.35–1.43] | 0.335 | ||
| Medical Doctors | 59 | 18 | 0.97 [0.68–1.38] | 0.850 | ||
| Ward Attendants | 23 | 6 | 1.00 [0.62–1.61] | 0.998 | - | - |
1N = 228, exposed HCWs/HCSs lost to follow (n = 36) and exposed HCWs/HCSs who truncated their schedule due to source patient testing HIV negative (n = 16) were excluded; 3TC = lamivudine; AZT = zidovudine; LPV-RTV = lopinavir-ritonavir; CI = confidence interval