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. 2015 Jun 15;11:1473–1482. doi: 10.2147/NDT.S80505

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© 2015 Han et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Coadministration of quetiapine protected rats against the ethanol-induced changes in redox status in PFC.

Notes: (A) Quetiapine prevented the ethanol-induced increase in ROS in PFC; (B) Quetiapine prevented the ethanol-induced decrease in catalase activity in PFC; (C) Quetiapine prevented the ethanol-induced decrease in TAC in PFC. Rats were killed by decapitation. Their brains were quickly removed and the PFC tissue samples were processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).

Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; QUE, quetiapine; PFC, prefrontal cortex; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity.