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. 2015 Jun 15;11:1473–1482. doi: 10.2147/NDT.S80505

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© 2015 Han et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Coadministration of quetiapine blocked the ethanol-induced oxidative stress in the hippocampus of rats.

Notes: (A) Quetiapine blocked the ethanol-induced increase in MDA; (B) Quetiapine blocked the ethanol-induced increase in ROS; (C) Quetiapine blocked the ethanol-induced increase in T-SOD; (D) Quetiapine blocked the ethanol-induced decrease in TAC. Rats were killed by decapitation. Their brains were quickly removed and the hippocampus tissue samples were processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).

Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; MDA, malondialdehyde; QUE, quetiapine; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity; T-SOD, total superoxide dismutase.