Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jun 15;11:1473–1482. doi: 10.2147/NDT.S80505

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 Han et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Coadministration of quetiapine blocked the ethanol-induced oxidative stress in the cerebellum of rats.

Notes: (A) Quetiapine blocked the ethanol-induced increase in MDA; (B) Quetiapine blocked the ethanol-induced increase in ROS; (C) Quetiapine blocked the ethanol-induced decrease in catalase; (D) Quetiapine blocked the ethanol-induced decrease in T-SOD; (E) Quetiapine blocked the ethanol-induced decrease in TAC. Rats were killed by decapitation. Their brains were quickly removed and the cerebellum tissue samples were processed for biochemical analyses. Data are expressed as mean ± SEM. *P<0.05, **P<0.01 (compared to CNT); ^#P<0.05 (QUE + ETH versus ETH).

Abbreviations: CNT, controls; ETH, ethanol; FI, fluorescence intensity; MDA, malondialdehyde; QUE, quetiapine; QUE + ETH, quetiapine plus ethanol; ROS, reactive oxygen species; SEM, standard error of mean; TAC, total antioxidant capacity; T-SOD, total superoxide dismutase.